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Carrn
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February 10, 2019
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BC I don't really know what the ATP and citrate status would be like under favorable conditions for gluconeogenesis...but I do know that excessive acetyl-CoA will be a part of its stimulation.
Posted on February 10, 2019 | score 0
Question: Acetyl-CoA in excess will also stimulate pyruvate carboxylase, which I presume is the enzyme responsible for converting the pyruvate directly to oxaloacetate in the mitochondria. This is also the first step of gluconeogenesis from pyruvate. Therefore, is the most relevant control which dictates fatty acid synthesis vs. gluconeogenesis the regulation by hormones (high PKA activity by glucagon will repress fatty acid synthesis, high phosphate activity by insulin activates it?)
Posted on February 10, 2019 | score 0