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Step 1 of Citric Acid Cycle (Part II)
The first step of the citric acid cycle is the formation of citrate from oxaloacetate and acetyl-CoA. This step is a two-step process that is catalyzed by an enzyme called citrate synthase. The first step of this process is an aldol condensation that produces an intermediate molecule called citryl-CoA. The citryl then undergoes a hydrolysis reaction that forms the citrate molecule. The citrate synthase enzyme is a dimer protein that consists of two identical subunits. The enzyme first binds oxaloacetate to its active site, which induces a conformational change that moves the catalytic residues into the proper orientation and creates a binding site for acetyl-CoA. This implies that acetyl-CoA can only bind to the enzyme after the oxaloacetate has bound to it.
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