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Proteolytic Activation
Another method by which cells can regulate the activity of enzymes is via proteolytic activation, also known as proteolytic cleavage or proteolysis. Certain enzymes are synthesized in their inactive form, called proenzymes or zymogens. To activate the activity of zymogens, these proenzymes are usually cleaved proteolytically by proteases. Once cleaved at one or several sites, the enzymes functionality is activated. There are many examples of enzymes that utitize this method, including digestive enzymes, blood-clotting enzymes, hormones, caspases (involved in apoptosis), collagen and collagenase (involved in building extracellular matrix).
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