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Post Translational Modifications
Once the polypeptide chain is synthesized by the ribosomes of the cell, it must undergo certain post-translational modifications in order to end up at its target location and become fully functional. Some of these post-translational modifications include phosphorylation, methylation, N-acetylation, glycosylation, lipidation and proteolysis. Once the protein is synthesized and in most instances during the translational process itself, the polypeptide chain by fold into its three-dimensional structure. Special proteins called chaperones assist the polypeptide chain in the folding process.
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